Science Deep Dive

Doctors Paradise PDRN+ Serum

About the product

The 07 Doctors Paradise PDRN+ Serum was developed for the seven dimensions of skin perfection: hydration, barrier comfort, soothing, microcirculation, matrix support, antioxidant protection, and renewal.

Developed for these seven dimensions, this serum activates the skin's regenerative mechanisms and effectively reduces visible signs of aging and environmental stress. It combines PDRN (polydeoxyribonucleotides) with skin-soothing, antioxidant, and structure-enhancing active ingredients. The focus is on stimulating cellular repair, strengthening the epidermal barrier, and promoting an even complexion.

The 07 PDRN+ Doctors Paradise Serum is a cosmeceutical. The term was coined in 1984 by Dr. Albert Kligman, a combination of cosmetics and pharmaceuticals, for skincare products that are applied externally like cosmetics but have pharmaceutical-like effects, with scientifically proven benefits and a very low risk profile.

  • For whom?

    For skin that is dry, easily irritated or prone to redness, as well as for first lines and decreasing elasticity.



  • For what?

    Supports regeneration signals, soothes irritation markers, binds water in multiple skin layers and protects surface lipids.



  • What will I see and when?

    After a few days, the skin appears more even and supple; after a few weeks, the texture becomes finer and the elasticity noticeably improved. Results may vary.

Dive Deep

Our active ingredient groups

Key active ingredient:
PDRN

RU21 Radiance Lift™

Multicomplex co-active ingredients
Part I

Multicomplex co-active ingredients
Part II

Indications and application

The 07 Doctors Paradise PDRN+ Serum is designed for all skin types. It is particularly recommended for dehydrated skin, tightness, reactive or redness-prone skin, first signs of fine lines, loss of elasticity, or a dull, uneven complexion. Depending on the needs of sensitive, easily stressed facial skin, the 07 Doctors Paradise PDRN+ Serum is the ideal choice alongside the all-rounder 06 360° Day & Night Serum.

Typical indications for users:

• Skin that is frequently exposed to environmental stressors such as dry air, travel, or air conditioning
• Lack of moisture and feelings of tension
• Reactive or redness-prone skin conditions
• First fine lines and decreasing elasticity
• Pale complexion and uneven texture


Expected results with consistent use of “07 Doctors Paradise PDRN+ Serum”

Shortly after application, the skin feels smoother and the surface has a more radiant glow.

Continuity is crucial. The results build up over days and weeks.

After a few days, the skin appears more balanced. A visibly calmer appearance is noticeable in areas that were previously red or uneven. A greater sense of comfort.

After 2 to 4 weeks, you will notice a significantly improved elasticity and a more even complexion. The texture appears finer.

After 8 weeks and beyond, the skin appears smoother overall and more resistant to everyday stress. Fine lines appear less pronounced.

Results vary from person to person. If you have recently undergone cosmetic treatments, it is recommended to consult with the treating clinic.

Operating principles

• Barrier & moisture management: Triple hyaluronic acid, NMF complex and glycerin support hydration and pH-dependent barrier enzymes.

Regeneration & Structure: PDRN modulates A2A signals, RU21 Radiance Lift™ with Palmitoyl Tripeptide-38 and peptides supports matrix-related markers.

• Calming & Tolerance: Centella triterpenes and postbiotic enzymes address stimulus-associated signals and microbiome strength.

• Antioxidant protection: Vitamin E and the polyphenol-rich Croton lechleri ​​extract contribute to the reduction of oxidative markers on the surface.

Conclusion

The "07" stands for the seven dimensions of skin balance:
Hydration, barrier comfort, soothing, microcirculation, matrix support, antioxidant protection and renewal.

The 07 Doctors Paradise PDRN+ Serum is the uncomplicated serum solution for dehydrated, reactive skin with first lines. PDRN supports regeneration signals, RU21 Radiance Lift™ addresses matrix-related markers, triple hyaluronic acid and NMF bind water in multiple layers, Centella soothes, enzymes stabilize the microbiome, and vitamin E and Dragon's Blood provide antioxidant surface protection. Visible results include a calmer, more even complexion and, over several weeks, a finer texture with improved elasticity. Results may vary.

Combined application: After applying O1 Gentle Glow Cleanser and O2 Glow & Protect Toner, apply a few pumps.
Apply 07 Doctors Paradise PDRN+ Serum, moisturize your eyes with 03 Bright Eyes Cream, finish with 08 360° All Day Protection Cream in the morning, and use 04 Skin Renewal Overnight Mask in the evening. Apply a thin layer consistently, morning and evening. First noticeable effects after a few days, with structural improvements continuing over weeks. Results may vary from person to person.

Literature & Transparency - Notes

Galeano M, Pallio G, Irrera N, Mannino F, Bitto A, Altavilla D, Vaccaro M, Squadrito G, Arcoraci V, Colonna MR, Lauro R, Squadrito F. Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing. Pharmaceuticals (Basel). 2021 Oct 29;14(11):1103. doi: 10.3390/ph14111103. PMID: 34832885; PMCID: PMC8618295.

Squadrito F, Bitto A, Altavilla D, Arcoraci V, De Caridi G, De Feo ME, Corrao S, Pallio G, Sterrantino C, Minutoli L, Saitta A, Vaccaro M, Cucinotta D. The effect of PDRN, an adenosine receptor A2A agonist, on the healing of chronic diabetic foot ulcers: results of a clinical trial. J Clin Endocrinol Metab. 2014 May;99(5):E746-53. doi: 10.1210/jc.2013-3569. Epub 2014 Jan 31. doi: 10.1210/jc.2014-4414. PMID: 24483158.


Cavallini M, Bartoletti E, Maioli L, Massirone A, Pia Palmieri I, Papagni M, Priori M, Trocchi G; As Members of The Polynucleotides HPT™ Priming Board, Collegio Italiano delle Società Scientifiche di Medicina Estetica (Italian College of the Aesthetic Medicine Scientific Societies) - SIME, AGORÀ, SIES. Consensus report on the use of PN-HPT™ (polynucleotides highly purified technology) in aesthetic medicine. J Cosmet Dermatol. 2021 Mar;20(3):922-928. doi: 10.1111/jocd.13679. Epub 2020 Sep 21. PMID: 32799391; PMCID: PMC7984045.

Su Z, Zheng Y, Yi J, Lai W, Ye C. The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study. J Cosmet Dermatol. 2025 Jul;24(7):e70324. doi: 10.1111/jocd.70324. PMID: 40682399; PMCID: PMC12274965.

Tai M, He Q, Lv P, Li W, Ling X, Li L, Guo M. Madecassoside alleviates PM2.5-Induced skin cell damage. Biochem Biophys Res Commun. 2025 Jul 12;770:151977. doi: 10.1016/j.bbrc.2025.151977. Epub 2025 May 12. PMID: 40378615.

Haftek M, Mac-Mary S, Le Bitoux MA, Creidi P, Seité S, Rougier A, Humbert P. Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin. Exp Dermatol. 2008 Nov;17(11):946-52. doi: 10.1111/j.1600-0625.2008.00732.x. Epub 2008 May 21. PMID: 18503551.

Marques C, Porcello A, Cerrano M, Hadjab F, Chemali M, Lourenço K, Hadjab B, Raffoul W, Applegate LA, Laurent AE. From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules. Biomolecules. 2025 Jan 19;15(1):148. doi: 10.3390/biom15010148. PMID: 39858543; PMCID: PMC11764130.


Oh N, Hwang J, Kang MS, Yoo CY, Kwak M, Han DW. Versatile and Marvelous Potentials of Polydeoxyribonucleotide for Tissue Engineering and Regeneration. Biomater Res. 2025 Apr 14;29:0183. doi: 10.34133/bmr.0183. PMID: 40231205; PMCID: PMC11994882.

Lampridou S, Bassett S, Cavallini M, Christopoulos G. The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review. J Cosmet Dermatol. 2025;24:e16721.

Veronesi F, Dallari D, Sabbioni G, Carubbi C, Martini L, Fini M. Polydeoxyribonucleotides (PDRNs) From Skin to Musculoskeletal Tissue Regeneration via Adenosine A2A Receptor Involvement. J Cell Physiol. 2017 Sep;232(9):2299-2307. doi: 10.1002/jcp.25663. Epub 2017 Mar 3. PMID: 27791262.

Rahman E, Carruthers JDA, Rao P, Abu-Farsakh HN, Garcia PE, Ioannidis S, Sayed K, Philipp-Dormston WG, Mosahebi A, Webb WR. Regenerative Aesthetics: A Genuine Frontier or Just a Facet of Regenerative Medicine: A Systematic Review. Aesthetic Plastic Surg. 2025 Jan;49(1):341-355. doi: 10.1007/s00266-024-04287-5. Epub 2024 Aug 28. PMID: 39198280.

Muhammad P, Novianto E, Setyorini M, Legiawati L, Yusharyahya SN, Menaldi SL, Budianti WK. Effectiveness of topical hyaluronic acid of different molecular weights in xerosis cutis treatment in elderly: a double-blind, randomized controlled trial. Arch Dermatol Res. 2024 Jun 3;316(6):329. doi: 10.1007/s00403-024-03003-2. PMID: 38829483.

Litwiniuk M, Krejner A, Speyrer MS, Gauto AR, Grzela T. Hyaluronic acid in inflammation and tissue regeneration. Wounds. 2016 Mar;28(3):78-88. PMID: 26978861.

Draelos ZD, Diaz I, Namkoong J, Wu J, Boyd T. Efficacy Evaluation of a Topical Hyaluronic Acid Serum in Facial Photoaging. Dermatol Ther (Heidelb). 2021 Aug;11(4):1385-1394. doi: 10.1007/s13555-021-00566-0. Epub 2021 Jun 26. PMID: 34176098; PMCID: PMC8322246.

Mentioned branded active ingredients from:

Sederma GmbH, D-41334 Nettetal, Kaldenkirchen

DSM Nutritional Products, 4002 Basel, Switzerland

ADEKA EUROPE GMBH, 40212 Düsseldorf

BASF Beauty Creations, 92593 Levallois-Perret Cedex, France

CODIF TECHNOLOGIE NATURELLE, 35417 Saint-Malo cedex, FRANCE

LIPOTEC SA, 08850 Gavà · Barcelona, ​​Spain

Induchem AG, 8604 Volketswil, Switzerland


The information on active ingredients and
The wording is intended for general information purposes. It is based on specialist literature.
and manufacturer data and do not replace individual advice.

Our products are cosmetics for
For external use only. They do not pursue any medical or therapeutic purpose.
Purpose. Instructions for injection applications refer exclusively to
medical contexts and not our products.

Information regarding studies refers to,
unless otherwise stated, individual active ingredients or general
Expert sources. They are not directly applicable to every end product.
The information on the respective product packaging is authoritative, including
the INCI list.

Proper application lies in
The user is responsible. Skin reactions can vary from person to person.
Do not use if you have a known intolerance to any of the ingredients.
Discontinue use if irritation occurs. If you have existing skin problems or after
Consult a doctor before using any product for aesthetic treatments.
For external use only. Not for injection. Avoid contact with eyes.
Avoid. Keep out of reach of children.

We are liable according to the statutory provisions.
Regulations. A limitation of liability for intent, gross negligence, and
No liability is assumed for injuries to life, body or health.

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the respective copyright holders. Content from this page may only be used with prior permission.
May be reproduced with written consent.