Science Deep Dive

Gentle Glow Cleanser

At the end of the day, you feel how much has accumulated on your skin. You want more than just cleansing; you want nourished, soothed, and prepared skin right from the start. The 01 Gentle Glow Cleanser is a medically developed cosmeceutical that applies the principles of preventative longevity to the very first step of your skincare routine. In line with the WHO's "Decade of Healthy Ageing" initiative, we pursue the goal of "healthspan optimization." Our formulations are based on the principles of "preventative longevity."

In this deep dive, you'll learn how our selected bioactive ingredients work deep within the skin's structure at a molecular level. We'll show you what they do, why we chose them, and how they help keep your skin healthy, resilient, and radiant.

Cosmeceuticals: Science meets nursing

The O1 Gentle Glow Cleanser is a cosmeceutical. The term was coined in 1984 by Dr. Albert Kligman, a combination of cosmetics and pharmaceuticals, for skincare products that are applied externally like cosmetics but have pharmaceutical-like effects, with scientifically proven benefits and a very low risk profile.

  • For whom?

    For all skin types, especially for dry, sensitive and redness-prone skin.

  • For what?

    Gentle, pH-friendly cleansing removes dirt, sunscreen residue and make-up, preserves lipids, supports the barrier and prepares for subsequent care.

  • What will I see and when?

    Instantly clear, soft skin feeling without tightness; with regular use, the surface appears calmer and more even.

Scientifically based anti-aging begins with cleansing. The 01 Gentle Glow Cleanser, a cosmeceutical cleanser, follows the principles of "preventive longevity" for clarified, strengthened skin that radiates from within.

Cleaning that can do more.

We developed the 01 Gentle Glow Cleanser to not only cleanse in the first step of your skincare routine, but also to actively contribute to your skin's health. It combines gentle cleansing with deeper nourishing effects: soothing, restoring, protecting, and providing lasting skin improvement right from the first step, and of course, it's free from ingredients classified as microplastics.

Dive Deep

Our active ingredient groups

RU21 Radiance Lift™ for building, smoothing and glow

Button label

Soothing & Protection: Natural Skin Balance

Button label

Structural design with a lifting effect at the molecular level

Button label

Scientifically sound application

According to standard dermatological literature, gel cleansing products with active ingredients should be applied to dry or only slightly damp skin. This prevents the active ingredient from becoming too diluted by water. The cleanser remains on dry skin for the longest time, which improves the absorption of the active ingredients.

A short application time of 30–60 seconds is recommended for bioactive cleansers to give the active ingredients enough contact time with the skin without irritating the skin barrier.

Some sources recommend not rinsing off cosmeceutical cleansers immediately, but rather gently massaging them in and allowing them to work. Pay particular attention to the T-zone. In dermatology, the T-zone refers to the area of ​​the face encompassing the forehead, nose, and chin, forming a "T" shape (increased sebum production → therefore often oilier, shinier, more prone to blemishes, enlarged pores, and blackheads). Rinse thoroughly with lukewarm water afterward and proceed with the next skincare step (toner) as usual. Depending on the severity of blemishes, it may be beneficial to cleanse the face twice a day. An external clinical study by Choi et al., 2010, suggests that using a mild cleanser twice daily for eight weeks as part of a skincare routine can improve the appearance of blemish-prone skin.

Literature & Transparency - Notes

Pandey A, Jatana GK, Sonthalia S. Cosmeceuticals. 2023 Aug 7. In:
StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–.
PMID: 31334943.


Badilli U, Inal O. Current Approaches in
Cosmeceuticals: Peptides, Biotics and Marine Biopolymers. Polymers (Basel).
2025 Mar 18;17(6):798. doi: 10.3390/polym17060798. PMID: 40292641; PMCID:
PMC11946782.


Bucur Popa RM, Radulescu C, Dulama ID, Stirbescu RM, Bucurica IA, Banica AL, Stanescu SG. Potential Health Risk of Microplastic Exposures from Skin-Cleansing Products. Toxics. 2025 Apr 29;13(5):354. doi: 10.3390/toxics13050354. PMID:
40423433; PMCID: PMC12116115.


Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci. 2009 Oct;31(5):327-45.
doi: 10.1111/j.1468-2494.2009.00490.x. Epub 2009 Jun 30. PMID: 19570099.


He M, Zhou P, Chen H, Zhang J, Zhang Y, Zheng X, Zhu W, Han L. (-)-α-Bisabolol inhibits D-Gal-induced HSF cellular senescence in vitro and prevents skin aging in vivo by reducing SASP. Iran J Basic Med Sci. 2024;27(9):1105-1114. doi: 10.22038/IJBMS.2024.76073.16469. PMID: 39055870; PMCID: PMC11266737.


Poljšak N, Kočevar Glavač N. Vegetable Butters and Oils as Therapeutically and Cosmetically Active Ingredients for Dermal Use: A Review of Clinical Studies. Front Pharmacol. 2022 Apr 25;13:868461. doi: 10.3389/fphar.2022.868461. PMID: 35548366; PMCID: PMC9083541.


Thiele JJ, Traber MG, Packer L. Depletion of human stratum corneum vitamin E: an early and sensitive in vivo marker of UV induced photo-oxidation. J Invest Dermatol. 1998 May;110(5):756-61. doi: 10.1046/j.1523-1747.1998.00169.x. PMID: 9579541.;


Zingg JM. Vitamin E: Regulatory Role on Signal Transduction. IUBMB Life. 2019 Apr;71(4):456-478. doi: 10.1002/iub.1986. Epub 2018 Dec 17. PMID: 30556637.)


Saturnino C, Sinicropi MS, Parisi OI, Iacopetta D, Popolo A, Marzocco S, Autore G, Caruso A, Cappello AR, Longo P, Puoci F. Acetylated hyaluronic acid: enhanced bioavailability and biological studies. Biomed Res Int. 2014;2014:921549. doi: 10.1155/2014/921549. Epub 2014 Jul 8.
PMID: 25114930; PMCID: PMC4121155.


Rona C, Vailati F, Berardesca E. The cosmetic treatment of wrinkles. J Cosmet Dermatol. 2004 Jan;3(1):26-34. doi: 10.1111/j.1473-2130.2004.00054.x. PMID: 17163944.


Garbuio DC, Ribeiro VDS, Hamamura AC, Faustino A, Freitas LAP, Viani G, Carvalho EC. A Chitosan-Coated Chamomile Microparticles Formulation to Prevent Radiodermatitis in Breast: A
Double-blinded, controlled, randomized, phase II clinical trial. At J Clin
Oncol. 2022 May 1;45(5):183-189. doi: 10.1097/COC.0000000000000905. Epub 2022 Apr 8. PMID: 35393979.


Choi JM, Lew VK, Kimball
AWAY. A single-blinded, randomized, controlled clinical trial evaluating the effect of face washing on acne vulgaris. Pediatric Dermatol. 2006 Sep-Oct;23(5):421-7. doi: 10.1111/j.1525-1470.2006.00276.x. PMID: 17014635.

Mentioned branded active ingredients from:

Sederma GmbH, D-41334 Nettetal, Kaldenkirchen

DSM Nutritional Products, 4002 Basel, Switzerland

ADEKA EUROPE GMBH, 40212 Düsseldorf

BASF Beauty Creations, 92593 Levallois-Perret Cedex, France

CODIF TECHNOLOGIE NATURELLE, 35417 Saint-Malo cedex, FRANCE

LIPOTEC SA, 08850 Gavà · Barcelona, ​​Spain

Induchem AG, 8604 Volketswil, Switzerland

The active ingredient information on this page is for general information purposes and is based on current specialist literature as well as data from our raw material suppliers.

Our products are designed for cosmetic use and do not claim to have any therapeutic effect. Results may vary from person to person. Use is at your own risk.

Internal user observation studies compiled feedback from clinical and home use on over 1,000 applications. This survey was non-interventional, without a control group or medical assessment; the analysis is based primarily on self-reported data and product feedback. It is not comparable to clinical studies but provides practical insights into skin feel and tolerability.

If you have known intolerances or existing skin problems, seek dermatological advice before use.

Note regarding fragrances:
If present, we use selected fragrances that are strictly regulated in the EU in very low concentrations, below known irritation thresholds.


Additional information:

The information on the respective product packaging, including the INCI list, is authoritative.

For external use only. Avoid contact with eyes. Keep out of reach of children.

Discontinue use and seek medical advice if irritation occurs. Do not use on broken skin.


Legal information:

Third-party brand and product names are used for identification purposes and are the property of their respective owners.


As of November 2025
Back to product