Science Deep Dive

Bright Eyes Cream

About the product

The 03 Bright Eyes Cream is designed for a radiant, awake-looking eye area. It focuses on targeted support of the extracellular matrix and barrier functions, combined with immediate plumping and long-lasting hydration. The 03 Bright Eyes Cream visibly reduces fine lines, strengthens the skin structure, and gives the eye area a fresh, luminous look for a bright, open gaze: Bright Eyes.

In this deep dive, you'll learn how our selected bioactive ingredients work deep within the skin's structure at a molecular level. We'll show you what they do, why we chose them, and how they help keep your skin healthy, resilient, and radiant.

The 03 Bright Eyes Cream is a cosmeceutical, a term coined in 1984 by Dr. Albert Kligman to combine cosmetics and pharmaceuticals. This class of skincare products is applied externally like cosmetics, but contains active ingredients of high purity and scientifically proven cosmetic benefits, with very good skin tolerance.

  • For whom?

    For all skin types; especially for dryness wrinkles, first fine lines and a sensitive, easily irritated eye area.

  • For what?

    Provides immediate hydration and barrier comfort, visually smooths and supports the dermal structure for a more alert appearance.

  • What will I see and when?

    Immediately a softer, smoother feel; after a few days a more even-looking contour; after 2–4 weeks finer-looking lines and increased elasticity. Results may vary.

Dive Deep

Our active ingredient groups

RU21 Radiance Lift™ for Biological Lifting & Wrinkle Reduction

Instant smoothing & visible firming

Deep Hydration & Barrier Care

Protection against oxidative stress & skin soothing

The periorbital region from a scientific perspective, or: What makes the eye area so special?

The skin around the eyes ages differently and faster if left untreated. It exhibits significant anatomical and dermatological differences compared to other areas of the face. These differences directly impact the aging behavior of this zone, which becomes clinically visible through the early appearance of wrinkles, loss of elasticity, and volume loss. The aging processes around the eyes are influenced internally by genetics and hormonal status, and externally by UV exposure and environmental factors.

The skin around the eyes is on average only about 0.33 mm thick and six times thinner than the skin on the cheek, which is about 2 mm thick. This is due to a thinner outer layer of skin (epidermis) and an almost non-existent layer of fat beneath the skin, the subcutis, which makes the skin particularly sensitive to external stimuli.

The skin around the eyes contains less sebum and fewer sweat glands. As a result, the skin is less hydrated and dries out more easily, which further promotes the formation of wrinkles.

The connective tissue is less tightly organized and loses elasticity more quickly due to the breakdown of collagen and elastin. Because of its reduced thickness and elasticity, dynamic wrinkles, such as laugh lines originating from the outer corner of the eye, often appear first around the eyes. This is because the eye area is the emotional center of our facial expressions. Repeated muscle movements and the lack of structural cushioning further accentuate these wrinkles.

UV radiation leads to the formation of free oxygen radicals, which is particularly effective in the area around the eyes. Oxidative stress and the associated inflammatory processes, via the factors interleukin-6 and TNF-α, lead to the accelerated degradation of the extracellular matrix.

The extracellular matrix (ECM) is the essential supporting and networking framework surrounding skin cells. Produced by connective tissue cells (fibroblasts), it determines the structure and function of the skin tissue around the eyes. It consists of collagen fibers (providing firmness), elastin (ensuring elasticity), hyaluronic acid (binding moisture), proteoglycans, and glycoproteins (mediating between cells and fibers). The ECM thus forms the "foundation" in the middle layer of the skin, which is the primary component of the skin around the eyes. It ensures that the skin remains elastic, plump, and resilient. Beginning in young adulthood, the ECM is broken down or damaged, which can lead to wrinkles, loss of elasticity, and dryness at an early age. Furthermore, the underlying subcutaneous fat and bony structure diminish over time, which can result in under-eye bags, shadows, and a sunken appearance around the eyes.


The skin around the eyes also ages due to communication between cells.

Over time, fibroblasts, the important connective tissue cells of the skin, enter a state of cellular aging (senescence) due to damage such as DNA alterations, shortened chromosome ends (telomeres), or free oxygen radicals, which the cells themselves also produce. These cells, colloquially referred to as "cell zombies" in scientific terms, no longer divide or renew themselves, but they remain active and secrete pro-inflammatory messenger substances.

Recent cell research shows that this so-called SASP (senescence-associated secretory phenotype) has a negative effect on surrounding cells. Its interaction with fat stem cells in the skin leads to chronic inflammation, collagen breakdown, and accelerated skin aging, particularly visible in the thin and sensitive periorbital skin around the eyes. It is essential to intervene in this disrupted cell communication and halt the aging process.

The periorbital eye area differs in that it has thinner skin, lower fat reserves, and fewer sebaceous glands. Therefore, it is particularly susceptible to early and visible signs of aging. Active ingredients for the periorbital eye area must thus be specifically formulated and dosed to address the anatomical and dermatological characteristics of this region. Furthermore, a base that does not migrate into the eyes is essential. The lipid-rich formula with fast-absorbing carriers helps to avoid over-treating or irritating the sensitive skin.

Conclusion

The 03 Bright Eyes Cream combines immediate effect with long-term effects: visibly smoother, firmer and more radiant eye areas, with evidence-based ingredients from peptide research and nature.

Literature & Transparency - Notes

Woo J, Ji H, Jeon K, Kim H, Yoon S, Hwang Y, Cho E, Park D, Jung E. Anti-skin aging effects of Gosori liquor lees extract by regulating interactions between senescent fibroblasts and adipose-derived stem cells. Int J Cosmet Sci. 2025 Jun;47(3):476-487. doi: 10.1111/ics.13046. Epub 2025 Jan 21. PMID: 39838700.

Elangwe CN, Morozkina SN, Olekhnovich RO, Polyakova VO, Krasichkov A, Yablonskiy PK, Uspenskaya MV. Pullulan-Based Hydrogels in Wound Healing and Skin Tissue Engineering Applications: A Review. Int J Mol Sci. 2023 Mar 4;24(5):4962. doi: 10.3390/ijms24054962. PMID: 36902394; PMCID: PMC10003054.


Hartini, H., Vlorensia, ., Abdullah, H., Martinus, A. and Ikhtiari, R. The Effect of a Moisturizing Cream Containing Saccharide Isomerate and Ceramide on Reducing Transepidermal Water Loss in Eczema. DOI: 10.5220/0009516204110417
In Proceedings of the International

Ambagaspitiya SS, Appuhamillage GA, Wimalawansa SJ. Impact of Vitamin D on Skin Aging, and Age-Related Dermatological Conditions. Front Biosci (Landmark Ed). 2025 Jan 20;30(1):25463. doi: 10.31083/FBL25463. PMID: 39862075.

Yuanxi L, Wei H, Lidan X, Li L. Comparison of skin hydration in combination and single use of common moisturizers (cream, toner, and spray water). J Cosmetic Sci. 2016 May-Jun;67(3):175-83. PMID: 29394018.

Tanaka M, Yamamoto Y, Misawa E, Nabeshima K, Saito M, Yamauchi K, Abe F, Furukawa F. Effects of Aloe Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial. Skin Pharmacol Physiol. 2016;29(6):309-317. doi: 10.1159/000454718. Epub 2017 Jan 14. PMID: 28088806.

Rev. Fac. Med. Hum. 2023; 23(1):110-120.

DOI: 10.25176/RFMH.v23i1.4341

PHARMACOLOGICAL EFFICACY OF ALOE VERA IN

WOUND HEALING: A NARRATIVE REVIEW

Blaak J, Staib P. An updated review on efficacy and benefits of sweet almond, evening primrose and jojoba oils in skin care applications. Int J Cosmet Sci. 2022 Feb;44(1):1-9. doi: 10.1111/ics.12758. Epub 2022 Jan 17. PMID: 34957578.

Meunier M, Scandolera A, Chapuis E, Lapierre L, Sandré J, Brunner G, Lovchik M, Reynaud R. The anti-wrinkles properties of sodium acetylated hyaluronate. J Cosmet Dermatol. 2022 Jul;21(7):2749-2762. doi: 10.1111/jocd.14539. Epub 2021 Oct 28. PMID: 34708918; PMCID: PMC9543187.

Burusapat C, Supawan M, Pruksapong C, Pitiseree A, Suwantemee C. Topical Aloe Vera Gel for Accelerated Wound Healing of Split-Thickness Skin Graft Donor Sites: A Double-Blind, Randomized, Controlled Trial and Systematic Review. Plast Reconstr Surg. 2018 Jul;142(1):217-226. doi: 10.1097/PRS.0000000000004515. PMID: 29649056.

Sharma S, Alfonso AR, Gordon AJ, Kwong J, Lin LJ, Chiu ES. Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review. Adv Skin Wound Care. 2022 Nov 1;35(11):1-9. doi: 10.1097/01.ASW.0000875056.29059.78. PMID: 36264753.

Bello I, Shehu MW, Musa M, Zaini Asmawi M, Mahmud R. Kigelia africana (Lam.) Benth. (Sausage tree): Phytochemistry and pharmacological review of a quintessential African traditional medicinal plant. J Ethnopharmacol. 2016 Aug 2;189:253-76. doi: 10.1016/j.jep.2016.05.049. Epub 2016 May 21. PMID: 27220655.

Pandey A, Jatana GK, Sonthalia S. Cosmeceuticals. 2023 Aug 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 31334943.

Mentioned branded active ingredients from:

Sederma GmbH, D-41334 Nettetal, Kaldenkirchen

DSM Nutritional Products, 4002 Basel, Switzerland

ADEKA EUROPE GMBH, 40212 Düsseldorf

BASF Beauty Creations, 92593 Levallois-Perret Cedex, France
CODIF TECHNOLOGIE NATURELLE, 35417 Saint-Malo cedex, FRANCE

LIPOTEC SA, 08850 Gavà · Barcelona, ​​Spain

Induchem AG, 8604 Volketswil, Switzerland

The active ingredient information on this page is for general information purposes and is based on current specialist literature as well as data from our raw material suppliers.

Our products are designed for cosmetic use and do not claim to have any therapeutic effect. Results may vary from person to person. Use is at your own risk.

Internal user observation studies compiled feedback from clinical and home use on over 1,000 applications. This survey was non-interventional, without a control group or medical assessment; the analysis is based primarily on self-reported data and product feedback. It is not comparable to clinical studies but provides practical insights into skin feel and tolerability.

If you have known intolerances or existing skin problems, seek dermatological advice before use.

Note regarding fragrances:
If present, we use selected fragrances that are strictly regulated in the EU in very low concentrations, below known irritation thresholds.


Additional information:

The information on the respective product packaging, including the INCI list, is authoritative.

For external use only. Avoid contact with eyes. Keep out of reach of children.

Discontinue use and seek medical advice if irritation occurs. Do not use on broken skin.


Legal information:

Third-party brand and product names are used for identification purposes and are the property of their respective owners.


As of November 2025